Ganglioside Function in Calcium Homeostasis and Signaling

  title={Ganglioside Function in Calcium Homeostasis and Signaling},
  author={Robert W. Ledeen and Gusheng Wu},
  journal={Neurochemical Research},
Ganglioside function in eukaryotic cells encompasses a variety of modulatory interactions related to both development and mature cellular behavior. In relation to the nervous system this includes induction of neurite outgrowth and trophic/neuroprotective phenomena; more generally this applies to ganglioside effects on receptor function, adhesion reactions, and signal transduction mechanisms in neural and extraneural systems. Underlying many of these trophic effects are ganglioside-induced… CONTINUE READING