Ganglioside Changes in Brain in Chronic Relapsing Experimental Allergic Encephalomyelitis Induced in the Lewis Rat

@article{Zaprianova1998GangliosideCI,
  title={Ganglioside Changes in Brain in Chronic Relapsing Experimental Allergic Encephalomyelitis Induced in the Lewis Rat},
  author={Emilia Zaprianova and Denislava D. Deleva and Andon Filchev},
  journal={Neurochemical Research},
  year={1998},
  volume={23},
  pages={1421-1425}
}
Chronic relapsing experimental allergic encephalomyelitis (CREAE) was induced in Lewis rats by inoculation with guinea-pig myelin and complete Freund's adjuvant followed by treatment with low-dose cyclosporin A. Rats were sacrified at different phases of the disease (just before the onset of clinical signs, during the first clinical episode of CREAE and during the first recovery). Gangliosides were extracted from the brain, analysed after purification by HPTLC fractionation and quantified… CONTINUE READING

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