Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene

@article{Santic2006GangliocytesIN,
  title={Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene},
  author={Radmila Santic and Katrin Fenninger and Kerstin Graf and Rainer Schneider and Cornelia Hauser-kronberger and Freimut H. Schilling and Per Kogner and Manfred Ratschek and Neil P. Jones and Wolfgang Sperl and Barbara Kofler},
  journal={Journal of Molecular Neuroscience},
  year={2006},
  volume={29},
  pages={145-152}
}
In neuroblastic tumors a relationship of differentiation of the tumor to galanin receptor expression and antip roliferative and apoptotic effects upon activation of galanin receptors in neuroblastoma cells was reported. To elucidate the expression of other components of the galanin peptide family in neuroblastic tumors, RT-PCR analysis of a variety of human neuroblastic tumor tissues was performed. Ganglioneuroma tissues revealed the presence of a splice variant of the galanin-like peptide… CONTINUE READING