Ganciclovir-loaded albumin nanoparticles: characterization and in vitro release properties.

  title={Ganciclovir-loaded albumin nanoparticles: characterization and in vitro release properties.},
  author={Marta Merodio and Amaia Arnedo and Mar{\'i}a Jes{\'u}s Renedo and Juan M Irache},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  volume={12 3},
Ganciclovir is one of the most widely used antiviral drug for the treatment of cytomegalovirus retinitis. Due to its short half-life in the vitreous, frequent administrations are necessary to maintain the therapeutic levels. In this context, the aim of this study was to characterise and in vitro evaluate the drug release properties of three different formulations of ganciclovir-loaded albumin nanoparticles. These carriers were prepared by a coacervation method and chemical cross-linking with… CONTINUE READING


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