Ganciclovir for cytomegalovirus: a call for indefinite prophylaxis in lung transplantation.

@article{Valentine2007GanciclovirFC,
  title={Ganciclovir for cytomegalovirus: a call for indefinite prophylaxis in lung transplantation.},
  author={Vincent G. Valentine and David R. Weill and Meera R. Gupta and Brad Raper and Stephanie G Laplace and Gisele A. Lombard and Ryan W. Bonvillain and David E. Taylor and Gundeep S Dhillon},
  journal={The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation},
  year={2007},
  volume={27 8},
  pages={
          875-81
        }
}
BACKGROUND Universal ganciclovir (GCV) prophylaxis is a strategy aimed at reducing cytomegalovirus (CMV) infection and delaying the development of bronchiolitis obliterans syndrome (BOS). However, the optimal duration of GCV prophylaxis remains unclear. We report our experience with GCV prophylaxis administered indefinitely and its effect on CMV pneumonitis, BOS and survival after lung transplantation (LT). METHODS One hundred fifty-one patients surviving >100 days after LT were analyzed. GCV… CONTINUE READING
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