Gammahydroxybutyrate: An endogenous regulator of energy metabolism
@article{Mamelak1990GammahydroxybutyrateAE, title={Gammahydroxybutyrate: An endogenous regulator of energy metabolism}, author={M. Mamelak}, journal={Neuroscience & Biobehavioral Reviews}, year={1990}, volume={13}, pages={187-198} }
Gammahydroxybutyrate is a naturally occurring metabolite of many mammalian tissues. Although its administration produces a wide range of pharmacological effects, its normal function has never been clearly defined. GHB can induce NREM and REM sleep, anaesthesia, hypothermia, and a trance-like state which has been considered a model for petit mal epilepsy. It markedly increases brain dopamine levels. It has been touted as a central neurotransmitter or neuromodulator, and high affinity brain… CONTINUE READING
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References
SHOWING 1-10 OF 166 REFERENCES
Evidence that a specific succinic semialdehyde reductase is responsible for λ‐hydroxybutyrate synthesis in brain tissue slices
- Chemistry, Medicine
- FEBS letters
- 1981
- 43
Relationship between pharmacological effects and blood and brain levels of gamma-butyrolactone and gamma-hydroxybutyrate.
- Chemistry, Medicine
- Biochemical pharmacology
- 1970
- 42
A comparison of the effects of γ-hydroxybutyrate and γ-butyrolactone on cerebral carbohydrate metabolism
- Chemistry
- 1979
- 11
Evidence for a role of high K
m aldehyde reductase in the degradation of endogenous γ‐hydroxybutyrate from rat brain
- Chemistry, Medicine
- FEBS letters
- 1985
- 26
A High‐Affinity, Na+‐Dependent Uptake System for γ‐Hydroxybutyrate in Membrane Vesicles Prepared from Rat Brain
- Biology, Medicine
- Journal of neurochemistry
- 1982
- 92
GAMMA‐HYDROXYBUTYRATE DEGRADATION IN THE BRAIN IN VIVO: NEGLIGIBLE DIRECT CONVERSION TO GABA
- Chemistry, Medicine
- Journal of neurochemistry
- 1976
- 51
Mechanism of the gamma-hydroxybutyrate-induced increase in brain dopamine and its relationship to "sleep".
- Chemistry, Medicine
- Biochemical pharmacology
- 1970
- 115