Gammahydroxybutyrate: An endogenous regulator of energy metabolism

@article{Mamelak1990GammahydroxybutyrateAE,
  title={Gammahydroxybutyrate: An endogenous regulator of energy metabolism},
  author={Mortimer Mamelak},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={1990},
  volume={13},
  pages={187-198}
}
  • M. Mamelak
  • Published 1 December 1989
  • Biology
  • Neuroscience & Biobehavioral Reviews
View on Elsevier
doi.org
159 Citations
Highly Influential Citations
4
Background Citations
53
Methods Citations
3
Results Citations
1

159 Citations

Gammahydroxybutyrate: An overview of the pros and cons for it being a neurotransmitter and/or a useful therapeutic agent

  • C. Cash
  • Biology, Psychology
    Neuroscience & Biobehavioral Reviews
  • 1994

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...

References

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Relationship between pharmacological effects and blood and brain levels of gamma-butyrolactone and gamma-hydroxybutyrate.

A comparison of the effects of γ-hydroxybutyrate and γ-butyrolactone on cerebral carbohydrate metabolism

The major qualitative difference between the two drugs was that higher doses of GBL were associated with additional decreases of citrate and glutamate, and it is proposed that these differences were secondary to hypercapnia and not due to a distinctive primary action of G BL.

Evidence for a role of high K m aldehyde reductase in the degradation of endogenous γ‐hydroxybutyrate from rat brain

A High‐Affinity, Na+‐Dependent Uptake System for γ‐Hydroxybutyrate in Membrane Vesicles Prepared from Rat Brain

A series of related compounds, including aryl‐or alkyl‐derivatives, has been examined for ability to inhibit GHB uptake, indicative of its possible physiological role and also of the existence of a high‐affinity uptake system for GHB.

GAMMA‐HYDROXYBUTYRATE DEGRADATION IN THE BRAIN IN VIVO: NEGLIGIBLE DIRECT CONVERSION TO GABA

The metabolism of γ‐hydroxybutyrate (GHB) was studied by following the fate of [1‐14C]GHB in mouse brain after an intravenous injection and the labelling pattern was consistent with the oxidation of GHB via succinate through the cycle, rather than with β‐oxidation ofGHB.

γ-Butyrolactone and γ-hydroxybutyric acid—I: Distribution and metabolism☆

Mechanism of the gamma-hydroxybutyrate-induced increase in brain dopamine and its relationship to "sleep".

Muscimol and γ-hydroxybutyrate: Similar interactions with convulsant agents

The effects of gamma-hydroxybutyrate on sleep.

It is suggested that GHB may serve as the prototype for a new class of hypnotic compounds derived from natural sources and capable of activating the neurological mechanisms of normal human sleep.
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