Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits.

@article{Ali2009GammadeltaTC,
  title={Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits.},
  author={Zahida Ali and Lin Yan and Nicholas Plagman and Armin Reichenberg and Martin Hintz and Hassan Jomaa and Francois Villinger and Z Chen},
  journal={Journal of immunology},
  year={2009},
  volume={183 8},
  pages={5407-17}
}
Vgamma2Vdelta2 T cells, a major human gammadelta T cell subset, recognize the phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by mycobacteria and some opportunistic pathogens, and they contribute to innate/adaptive/homeostatic and anticancer immunity. As initial efforts to explore Vgamma2Vdelta2 T cell-based therapeutics against HIV/AIDS-associated bacterial/protozoal infections and neoplasms, we investigated whether a well-defined HMBPP/IL-2 therapeutic regimen… CONTINUE READING

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