GammaH2AX as a molecular marker of aging and disease.

Abstract

Double-strand breaks are one of the most critical DNA lesions with respect to cell-death and preservation of genomic integrity. Rapid phosphorylation of the histone variant H2AX at Ser-139 to form gammaH2AX is an early cellular response to DNA double-strand breaks. Visualization of discrete gammaH2AX foci using immunofluorescence-based assays has provided a sensitive and effective method for detecting DSBs which may be implicated in various pathologies including cancer, age-related diseases, chronic inflammatory diseases and ischemia-reperfusion injury. In this review, the potential utility and significance of gammaH2AX as a molecular marker of aging and disease is analysed.

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@article{Mah2010GammaH2AXAA, title={GammaH2AX as a molecular marker of aging and disease.}, author={Li-Jeen Mah and Assam El-Osta and Tom C. Karagiannis}, journal={Epigenetics}, year={2010}, volume={5 2}, pages={129-36} }