Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds

@article{Kushner1997GammavinylGA,
  title={Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds},
  author={Stephanie A. Kushner and Stephen L. Dewey and Conan Kornetsky},
  journal={Psychopharmacology},
  year={1997},
  volume={133},
  pages={383-388}
}
 Gamma-vinyl GABA (GVG, also referred to as vigabatrin), an irreversible inhibitor of GABA transaminase (GABA-T), raises levels of GABA in nerve terminals, inhibits striatal dopamine release, and attenuates cocaine-induced increases in extracellular dopamine in the striatum and nucleus accumbens. In order to determine the action of GVG on dopamine-mediated reward, we examined its effects on the threshold for rewarding brain stimulation in male F-344 rats. GVG dose-dependently raised brain… CONTINUE READING