Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.

@article{Kannappan2010GammatocotrienolPT,
  title={Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.},
  author={Ramaswamy Kannappan and Jayaraj Ravindran and Sahdeo Prasad and Bokyung Sung and Vivek R. Yadav and Simone Reuter and Madan Mohan Chaturvedi and Bharat Bhushan Aggarwal},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 8},
  pages={
          2196-207
        }
}
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor superfamily, is in clinical trials for cancer therapy, but its anticancer potential is limited by the development of resistance. We investigated the ability of tocotrienol (T3), an unsaturated vitamin E present in palm oil, rice bran, barley, oats, and wheat germ, to sensitize tumor cells to TRAIL. Results from esterase staining, colony formation, caspase activation, and sub-G(1) cell cycle… CONTINUE READING
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