Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways.

@article{Pan2002GammasynucleinPC,
  title={Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways.},
  author={Zhongzong Pan and Wendy Bruening and Benoit I Giasson and Virginia M-Y Lee and Andrew K. Godwin},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 38},
  pages={35050-60}
}
Synucleins are a family of highly conserved small proteins predominantly expressed in neurons. Recently we and others have found that gamma-synuclein is dramatically up-regulated in the vast majority of late-stage breast and ovarian cancers and that gamma-synuclein over-expression can enhance tumorigenicity. In the current study, we have found that gamma-synuclein is associated with two major mitogen-activated kinases (MAPKs), i.e. extracellular signal-regulated protein kinases (ERK1/2) and c… CONTINUE READING
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