Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block.

Abstract

The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (Po) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits or of all three subunits (i.e., αγ- and αβγ-channels). A mutant channel comprised of… (More)
DOI: 10.1152/ajprenal.00337.2013

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