Gamma-secretase inhibition and modulation for Alzheimer's disease.

  title={Gamma-secretase inhibition and modulation for Alzheimer's disease.},
  author={Michael S Wolfe},
  journal={Current Alzheimer research},
  volume={5 2},
Gamma-secretase is a multi-protein complex that proteolyzes the transmembrane region of the amyloid beta-peptide (Abeta) precursor (APP), producing the Abeta peptide implicated in the pathogenesis of Alzheimer's disease (AD). This protease has been a top target for AD, and various inhibitors have been identified, including transition-state analogue inhibitors that interact with the active site, helical peptides that interact with the initial substrate docking site, and other less peptide-like… CONTINUE READING


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