Gamma-secretase-dependent proteolysis of CD44 promotes neoplastic transformation of rat fibroblastic cells.

@article{Pelletier2006GammasecretasedependentPO,
  title={Gamma-secretase-dependent proteolysis of CD44 promotes neoplastic transformation of rat fibroblastic cells.},
  author={Ludivine Pelletier and Patricia Guillaumot and Barbara Fr{\^e}che and C{\'e}line Luquain and Dale Christiansen and Sabine Brugi{\`e}re and J{\'e}r{\^o}me Garin and Serge N. Mani{\'e}},
  journal={Cancer research},
  year={2006},
  volume={66 7},
  pages={3681-7}
}
The metalloprotease-dependent extracellular domain cleavage of the adhesion molecule CD44 is frequently observed in human tumors and is thought to promote metastasis. This cleavage is followed by gamma-secretase-dependent release of CD44 intracellular domain (CD44-ICD), which exhibits nuclear signaling activity. Using a reversible Ret-dependent oncogenic conversion model and a restricted proteomic approach, we identified a positive correlation between the neoplastic transformation of Rat-1… CONTINUE READING

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