Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

@article{Tsao2008GammasecretaseAO,
  title={Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.},
  author={P -N Tsao and Felicia F. Chen and Konstantin I Izvolsky and Janice Walker and Maria A. Kukuruzinska and Jining Lu and Wellington V Cardoso},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 43},
  pages={29532-44}
}
Little is known about the mechanisms by which the lung epithelial progenitors are initially patterned and how proximal-distal boundaries are established and maintained when the lung primordium forms and starts to branch. Here we identified a number of Notch pathway components in respiratory progenitors of the early lung, and we investigated the role of Notch in lung pattern formation. By preventing gamma-secretase cleavage of Notch receptors, we have disrupted global Notch signaling in the… CONTINUE READING