Gamma-secretase activating protein, a therapeutic target for Alzheimer's disease

  title={Gamma-secretase activating protein, a therapeutic target for Alzheimer's disease},
  author={Gen He and Wenjie Luo and Peng P. Li and Christine Remmers and William Joseph Netzer and Joseph P. Hendrick and Karima Bettayeb and Marc Flajolet and Fred S. Gorelick and Lawrence Paul Wennogle and Paul Greengard},
Accumulation of neurotoxic amyloid-β is a major hallmark of Alzheimer’s disease. Formation of amyloid-β is catalysed by γ-secretase, a protease with numerous substrates. Little is known about the molecular mechanisms that confer substrate specificity on this potentially promiscuous enzyme. Knowledge of the mechanisms underlying its selectivity is critical for the development of clinically effective γ-secretase inhibitors that can reduce amyloid-β formation without impairing cleavage of other… CONTINUE READING
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