Gamma scintigraphic evaluation of film-coated tablets intended for colonic or biphasic release.

@article{OforiKwakye2004GammaSE,
  title={Gamma scintigraphic evaluation of film-coated tablets intended for colonic or biphasic release.},
  author={Kwabena Ofori-Kwakye and John T. Fell and Harbans L. Sharma and A P Smith},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={270 1-2},
  pages={307-13}
}
The gastrointestinal transit and in vivo drug release behaviour of a film-coated tablet formulation was investigated in five healthy human subjects using the technique of gamma scintigraphy. The film coating system consisted of a mixture of pectin, chitosan and HPMC in a ratio of 6:1:0.37 applied to 750 mg cores at a coat weight gain of 9%. The estimated mean values of the gastric emptying time (62+/-17 min), small intestinal transit time (219+/-53 min), ileocaecal junction lag time (79+/-30… CONTINUE READING

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