Gamma-radiation upregulates MHC class I/II and ICAM-I molecules in multiple myeloma cell lines and primary tumors

@article{ChirivaInternati2006GammaradiationUM,
  title={Gamma-radiation upregulates MHC class I/II and ICAM-I molecules in multiple myeloma cell lines and primary tumors},
  author={M. Chiriva-Internati and Fabio Grizzi and Justin R. Pinkston and K. John Morrow and Nicholas D'cunha and Ermenegildo Eldo Frezza and Pier Carlo Muzzio and Wijbe Martin Kast and E Berrobianco Cobos},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2006},
  volume={42},
  pages={89-95}
}
The γ-irradiation of normal cells causes an increased synthesis of specific proteins. However, few studies have described the effects of high doses of irradiation on the expression of cell surface antigens in tumor cells. This study analyzed the effects of high doses of γ-irradiation on the surface antigen expression of Major Histocompatability Complex (MHC) class I/II and intercellular adhesion molecule-1 (ICAM-I) in human multiple myeloma (MM) cell lines ARP-1, ARK-RS, and 10 MM primary… CONTINUE READING
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