Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo.

@article{Kitada1996GammaradiationIU,
  title={Gamma-radiation induces upregulation of Bax protein and apoptosis in radiosensitive cells in vivo.},
  author={Shinichi Kitada and Stan Stanislaw Krajewski and Toshiyuki Miyashita and Maryla Krajewska and John C. Reed},
  journal={Oncogene},
  year={1996},
  volume={12 1},
  pages={187-92}
}
Lymphoid cells and small intestinal epithelial (SIE) cells are among the most radiosensitive in the body. The factors that account for the differential sensitivity to gamma-radiation among different tissue-types remain poorly understood, but can only partly be explained by differences in rates of cell proliferation. Here we demonstrate that exposure of mice to 800 cGy of gamma-radiation results in rapid elevations in the levels of the Bax protein, a pro-apoptotic member of the Bcl-2 protein… CONTINUE READING
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