Gamma-protocadherins are targeted to subsets of synapses and intracellular organelles in neurons.

  title={Gamma-protocadherins are targeted to subsets of synapses and intracellular organelles in neurons.},
  author={Greg R Phillips and Hidekazu Tanaka and Marcus Frank and Alice M Elste and Lazar Fidler and Deanna L. Benson and David R. Colman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={23 12},
The clustered protocadherins (Pcdhs) comprise >50 putative synaptic recognition molecules that are related to classical cadherins and highly expressed in the nervous system. Pcdhs are organized into three gene clusters (alpha, beta, and gamma). Within the alpha and gamma clusters, three exons encode the cytoplasmic domain for each Pcdh, making these domains identical within a cluster. Using an antibody to the Pcdh-gamma constant cytoplasmic domain, we find that all interneurons in cultured… CONTINUE READING
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