Gamma-interferon production capacity and T lymphocyte subpopulation after allogeneic bone marrow transplantation.

@article{Mizuno1986GammainterferonPC,
  title={Gamma-interferon production capacity and T lymphocyte subpopulation after allogeneic bone marrow transplantation.},
  author={Shinya Mizuno and Yasuo Morishima and Yoshihisa Kodera and Ryuzo Ohno and Shozo Yokomaku and Hiroshi Sao and Satoshi Yoshikawa},
  journal={Transplantation},
  year={1986},
  volume={41 3},
  pages={311-5}
}
T cell phenotypes after bone marrow transplantation (BMT) were investigated using monoclonal antibodies (moAbs) reactive to lymphocyte cell surface antigens. Patients' T cells showed decreased percentages of OKT4, 4A and 9.3-positive T cells, and increased percentages of OKT8, human Ia, and Leu-7-positive T cells. These changes in T cell phenotype persisted for a long period after BMT and had no correlation with the occurrence of graft-versus-host disease (GVHD). No lymphocyte activation… CONTINUE READING

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These changes in T cell phenotype persisted for a long period after BMT and had no correlation with the occurrence of graft - versus - host disease ( GVHD ) .
The capacity of the patients ' lymphocytes to produce gamma - interferon ( IFN - gamma ) was measured after incubation of lymphocytes with mitogen .
The capacity of the patients ' lymphocytes to produce gamma - interferon ( IFN - gamma ) was measured after incubation of lymphocytes with mitogen .
These changes in T cell phenotype persisted for a long period after BMT and had no correlation with the occurrence of graft - versus - host disease ( GVHD ) .
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