Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action.

@article{Phan2000GammainterferoninducibleLT,
  title={Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action.},
  author={Uyen T. Phan and Balasubramanian Arunachalam and Peter Cresswell},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 34},
  pages={25907-14}
}
We recently identified a gamma-interferon-inducible lysosomal thiol reductase (GILT), constitutively expressed in antigen-presenting cells, that catalyzes disulfide bond reduction both in vitro and in vivo and is optimally active at acidic pH. GILT is synthesized as a 35-kDa precursor, and following delivery to major histocompatibility complex (MHC) class II-containing compartments (MIICs), is processed to the mature 30-kDa form via cleavage of N- and C-terminal propeptides. The generation of… CONTINUE READING
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