Gamma interferon-induced guanylate binding protein 1 is a novel actin cytoskeleton remodeling factor.

@article{Ostler2014GammaIG,
  title={Gamma interferon-induced guanylate binding protein 1 is a novel actin cytoskeleton remodeling factor.},
  author={Nicole Ostler and Nathalie Britzen-Laurent and Andrea Liebl and Elisabeth Naschberger and Guenter Lochnit and Markus Ostler and Florian Forster and Peter Kunzelmann and Semra Ince and Verena Supper and Gerrit J. K. Praefcke and Dirk W. Schubert and Hannes Stockinger and Christian Herrmann and Michael St{\"u}rzl},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 2},
  pages={196-209}
}
Gamma interferon (IFN-γ) regulates immune defenses against viruses, intracellular pathogens, and tumors by modulating cell proliferation, migration, invasion, and vesicle trafficking processes. The large GTPase guanylate binding protein 1 (GBP-1) is among the cellular proteins that is the most abundantly induced by IFN-γ and mediates its cell biologic effects. As yet, the molecular mechanisms of action of GBP-1 remain unknown. Applying an interaction proteomics approach, we identified actin as… CONTINUE READING