Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages.

@article{Lah1995GammainterferonCA,
  title={Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages.},
  author={Tamara T Lah and Michael Hawley and Kenneth L. Rock and Alfred L Goldberg},
  journal={FEBS letters},
  year={1995},
  volume={363 1-2},
  pages={85-9}
}
Previous studies have indicated that acid-optimal cysteine proteinase(s) in the endosomal-lysosomal compartments, cathepsins, play a critical role in the proteolytic processing of endocytosed proteins to generate the antigenic peptides presented to the immune system on major histocompatibility complex (MHC) class II molecules. The presentation of these peptides and the expression of MHC class II molecules by macrophages and lymphocytes are stimulated by gamma-interferon (gamma-IFN). We found… CONTINUE READING

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