Gamma interferon-based immunodiagnosis of tuberculosis: comparison between whole-blood and enzyme-linked immunospot methods.

@article{Schlvinck2004GammaII,
  title={Gamma interferon-based immunodiagnosis of tuberculosis: comparison between whole-blood and enzyme-linked immunospot methods.},
  author={Elisabeth Sch{\"o}lvinck and Katalin A Wilkinson and Adam O Whelan and Adrian R Martineau and Michael Levin and Robert J Wilkinson},
  journal={Journal of clinical microbiology},
  year={2004},
  volume={42 2},
  pages={
          829-31
        }
}
The gamma interferon secretion levels of 52 adults whose T cells had been stimulated with the Mycobacterium tuberculosis antigens CFP-10 and ESAT-6 were measured by enzyme-linked immunospot methods and a whole-blood-based assay. The test results correlated well (r = 0.689, P < 0.0001). Its simple format and use of only small volumes of blood make the whole-blood assay suitable for pediatric practice and field trials. 

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