Gamma-hydroxybutyric acid: an evaluation of its rewarding properties in rats and mice.

@article{Fattore2000GammahydroxybutyricAA,
  title={Gamma-hydroxybutyric acid: an evaluation of its rewarding properties in rats and mice.},
  author={L Fattore and Maria Cristina Martellotta and Gregorio Cossu and Walter Fratta},
  journal={Alcohol},
  year={2000},
  volume={20 3},
  pages={
          247-56
        }
}
Gamma-hydroxybutyric acid, an endogenous compound present in mammalian brain and supposed to be a neurotransmitter or neuromodulator, has been shown to affect several aspects of dependence from some drugs of abuse. It has been successfully used in clinical practice to alleviate both alcohol and opiate withdrawal symptoms. The aim of this study was to investigate whether gamma-hydroxybutyric acid possesses rewarding properties by means of conditioned place preference and intravenous self… CONTINUE READING
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