Gamma-hydroxybutyrate Reduces GABAA-mediated Inhibitory Postsynaptic Potentials in the CA1 Region of Hippocampus

@article{Cammalleri2002GammahydroxybutyrateRG,
  title={Gamma-hydroxybutyrate Reduces GABAA-mediated Inhibitory Postsynaptic Potentials in the CA1 Region of Hippocampus},
  author={Maurizio Cammalleri and Alfredo Brancucci and Fulvia Berton and Antonella Loche and Gian Luigi Gessa and Walter Francesconi},
  journal={Neuropsychopharmacology},
  year={2002},
  volume={27},
  pages={960-969}
}
Gamma-hydroxybutyric acid (GHB) is a psychoactive drug and a putative neurotransmitter, derived from gamma-aminobutyric acid (GABA). At micromolar concentrations GHB binds to specific high and low affinity binding sites present in discrete areas of the brain, while at millimolar concentrations GHB also binds to GABAB receptors. Previous studies indicated that GHB inhibits both NMDA and AMPA receptor mediated excitatory postsynaptic potentials in hippocampal CA1 pyramidal neurons. This action of… CONTINUE READING
9 Extracted Citations
57 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-9 of 9 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 57 references

Therapeutic uses of GHB

  • R Agabio, GL Gessa
  • 2002
3 Excerpts

Relation of the [ 3 H ] gamma - hydroxybu - tyric acid ( GHB ) binding site to the gamma - aminobu - tyric acidB ( GABAB ) receptor in rat brain

  • MK Tallent, SG Madamba, GR Siggins
  • Biochem Pharmacol
  • 2001
2 Excerpts

Similar Papers

Loading similar papers…