Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.

Abstract

Gamma-Glutamyltranspeptidase (GGT) catalyzes the first step in the extracellular hydrolysis of glutathione (GSH) and plays a critical role in GSH recycling; however, little is known about the impact of diminished GGT activity on immune function. We report here that GGT knockout (GGT(-/-)) mice have a 30 % decrease in splenic GSH and a 50 % reduction in… (More)

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@article{Lawrence2000GammaglutamyltranspeptidaseKM, title={Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.}, author={B. Paige Lawrence and Yvonne Will and Donald J. Reed and Nancy I Kerkvliet}, journal={European journal of immunology}, year={2000}, volume={30 7}, pages={1902-10} }