Gamma-glutamylcysteine ethyl ester protection of proteins from Abeta(1-42)-mediated oxidative stress in neuronal cell culture: a proteomics approach.

@article{BoydKimball2005GammaglutamylcysteineEE,
  title={Gamma-glutamylcysteine ethyl ester protection of proteins from Abeta(1-42)-mediated oxidative stress in neuronal cell culture: a proteomics approach.},
  author={Debra Boyd-Kimball and Rukhsana Sultana and Hung Fai Poon and Hafiz Mohmmad-Abdul and Bert C. Lynn and Jon B. Klein and David Butterfield},
  journal={Journal of neuroscience research},
  year={2005},
  volume={79 5},
  pages={707-13}
}
Protein oxidation mediated by amyloid beta-peptide (1-42) (Abeta[1-42]) has been proposed to play a central role in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder associated with aging and the loss of cognitive function. The specific mechanism by which Abeta(1-42), the primary component of the senile plaque and a pathologic hallmark of AD, contributes to the oxidative damage evident in AD brain is unknown. Moreover, the specific proteins that are vulnerable to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…