Gamma-glutamyl transpeptidase.

  title={Gamma-glutamyl transpeptidase.},
  author={Sidney B. Rosalki},
  journal={Advances in clinical chemistry},
  • S. Rosalki
  • Published 1975
  • Biology
  • Advances in clinical chemistry
Gama-Glutamyl Transpeptidase and Glutathione Function
γ-Glutamyl transpeptidase, a plasma membrane-associated enzyme that is located on the outer surface of the cells of secretory tissues, plays a central role in the metabolism of glutathione that is widely in various mammals.
Effects of alcohol on gamma-glutamyl transpeptidase (GGTP).
  • E. Reyes
  • Biology, Chemistry
    Advances in experimental medicine and biology
  • 1980
There is evidence to suggest that the enzyme is involved in the active transport of amino acids and biogenic amines across the blood-brain-barrier via the γ-glutamyl cycle.
Gamma Glutamyl Transferase
  • J. Whitfield
  • Medicine
    Critical reviews in clinical laboratory sciences
  • 2001
This review aims to summarize the knowledge about GGT's clinical applications, to present information on its physiological roles, consider the results of epidemiological studies, and assess how far these separate areas can be combined into an integrated view.
Gamma-glutamyl transpeptidase: redox regulation and drug resistance.
  • M. Hanigan
  • Biology, Medicine
    Advances in cancer research
  • 2014
Isolation of gamma-glutamyltransferase from human liver, and comparison with the enzyme from human kidney.
Lectin-binding property differences are retained for the trypsinized form of the liver and kidney enzymes, although the degree of precipitation was less for certain lectins as compared to the untreated enzyme.
Isolationof ‘ y-Glutamyltransferasefrom Human Liver , and Comparison with the Enzyme from Human Kidney
Major differences were observed in the lectin-binding properties of liver -y-glutamyltransferase compared to the kidney enzyme, especially in the trypsinized form of the liver and kidney enzymes.


Gamma Glutamyl Transpeptidase: Measurement and Development in Guinea Pig Small Intestine
This simple enzyme assay, stability of the enzyme when frozen, subcellular distribution in the intestinal brush border membrane, and an unusual developmental pattern made this enzyme a useful adjunct to the study of intestinal protein metabolism, suggesting a role for this enzyme in the metabolism of an unusual group of physiologically important peptides.
Serum gamma-glutamyl transpeptidase activity in myocardial ischaemia.
Changes in levels of this enzyme might help in distinguishing patients with myocardial infarction from those presenting similarly but showing no evidence of myocardIAL necrosis, as judged by the appearance of serial electrocardiograms and the observation of the serum activity of other enzymes whose place in the diagnosis of my cardiac infarctions is well established.
Determination of Serum γ-Glutamyl Transpeptidase Activity and its Clinical Applications
The L-y-g1utamyl-p-nitroanilide concentration of the substrate and pH chosen were those suggested by Orlowski (1965) and this concentration was found to be optimal, but because of the lower volume of serum in the incubation mixture the final concentration in the reaction mixture is slightly higher (5.6 mmol/I instead of 5·0 mmol/l).
Serum gamma-glutamyl transpeptidase activity in myocardial infarction.
The study of serum y-glutamyl transpeptidase activity in hepatobiliary disease has recently aroused much clinical interest and was suggested by the importance of glutamic acid in heart metabolism and by the increase of this amino acid in the serum of patients with myocardial infarction.
Serum γ-glutamyl transpeptidase activity in liver disease
The apparent effect of certain drugs on serum GGT activity indicates the need for caution in interpreting the results of this test, and patients who had been treated with phenytoin and barbiturates were found to have elevated serum G GT activities without any other evidence of liver disease.
An automated method for the determination of serum -glutamyltranspeptidase.