Gamma-glutamyl transpeptidase is up-regulated on memory T lymphocytes.

  title={Gamma-glutamyl transpeptidase is up-regulated on memory T lymphocytes.},
  author={David R. Karp and Margaret L Carlisle and Angela B. Mobley and Timothy C Nichols and Nancy Oppenheimer-Marks and Ruth I. Brezinschek and V. Michael Holers},
  journal={International immunology},
  volume={11 11},
The ectoenzyme gamma-glutamyl transpeptidase (GGT) hydrolyzes glutathione (GSH), is required for the maintenance of normal intracellular GSH levels and modifies the activity of GSH-containing adducts. Previous data suggested that this enzyme was present on mitogen-activated T lymphocytes. However, the level of GGT protein expression on human mononuclear cell subsets has not been determined. A novel mAb to human GGT, 3A8, was developed. 3A8 was used to show that the expression of GGT is, in fact… CONTINUE READING


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