• Corpus ID: 82052645

Gamma-glutamyl compounds in human tissues

@inproceedings{Hammond1995GammaglutamylCI,
  title={Gamma-glutamyl compounds in human tissues},
  author={Judith Hammond},
  year={1995}
}
The unusual structure of y-glutamyl amino acids makes them resistant to hydrolysis by peptidases. Instead they are degraded by y-glutamyltransferase (y-GT) and y-glutamyl amino acid cyclotransferase. In this study the compounds excreted by patients with the rare disorder, y-GT deficiency, demonstrated the probable physiological substrates and role of y-GT in the human kidney. Abnormal metabolites excreted were reduced glutathione, y-glutamylcysteine, y-glutamylglutamine, y-glutamyl-a… 
Reduced glutathione, γ-glutamylcysteine, cysteine and γ-glutamylglutamine in γ-glutamyltransferase deficiency
TLDR
Thiols and peptides containing thiols are subject to thiol-thiol oxidation and disulphide exchange as well as enzymatic hydrolysis, and metabolites related to γ-GT deficiency are studied.

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TLDR
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