Gamma globulin levels predict type 2 diabetes in the Pima Indian population.

  title={Gamma globulin levels predict type 2 diabetes in the Pima Indian population.},
  author={Robert S. Lindsay and Jonathan Krakoff and Robert L Hanson and Peter H. Bennett and William C. Knowler},
  volume={50 7},
It has been proposed that inflammation or infection may contribute to the development of type 2 diabetes. We examined whether serum gamma globulin, a nonspecific measure of the humoral immune system, predicted changes in glucose tolerance in 2,530 members of the Pima Indian population, a group with a marked predisposition to type 2 diabetes. Cross-sectionally, gamma globulin was positively related to age (r = 0.08, P < 0.0005), BMI (r = 0.09; P < 0.0001), and female sex (P < 0.0001). Gamma… CONTINUE READING


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