Corpus ID: 24957603

Gamma-fluorinated analogues of glutamic acid and glutamine.

@article{Dave2003GammafluorinatedAO,
  title={Gamma-fluorinated analogues of glutamic acid and glutamine.},
  author={R. Dave and B. Badet and P. Meffre},
  journal={Amino acids},
  year={2003},
  volume={24 3},
  pages={
          245-61
        }
}
Gamma-fluorinated analogues of glutamic acid and glutamine are compounds of biological interest. Syntheses of such compounds are extensively reviewed in this article. 4-fluoroglutamic acid was prepared as a mixture of racemic diastereomers by Michael reaction, inverse-Michael reaction or by electrophilic / nucleophilic fluorination. Optically enriched 4-fluoroglutamic acids were obtained by several resolution techniques as well as by asymmetric methodologies using the chiral pool. 4… Expand