Gamma delta intraepithelial lymphocytes drive tumor necrosis factor-alpha responsiveness to intestinal iron challenge: relevance to hemochromatosis.

@article{Elshof1999GammaDI,
  title={Gamma delta intraepithelial lymphocytes drive tumor necrosis factor-alpha responsiveness to intestinal iron challenge: relevance to hemochromatosis.},
  author={A E Ten Elshof and Gary M. Brittenham and Karen A Chorney and Michael J. Page and Glenn Gerhard and Edward Earl Cable and Michael Chorney},
  journal={Immunological reviews},
  year={1999},
  volume={167},
  pages={223-32}
}
The dependence of intestinal epithelial cell (IEC) growth and differentiation on intraepithelial lymphocytes (IELs) expressing the gamma/delta (gamma delta) T-cell receptor (TCR), suggested a potential role for gamma delta + IELs in the regulation of iron absorption. We therefore examined the levels of hepatic iron and the IEL cytokine responses in C57BL/6J control and class I and TCR knockout lines (placed on a C57BL/6J genetic background) following the administration of supplemental dietary… CONTINUE READING
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