Gamma delta T cells recognize haptens and mount a hapten-specific response

@inproceedings{Zeng2014GammaDT,
  title={Gamma delta T cells recognize haptens and mount a hapten-specific response},
  author={Xun Zeng and Christina Meyer and Jun Huang and Brian A. Kidd and Yu-ling Wei and Yueh-hsiu Chien},
  booktitle={eLife},
  year={2014}
}
The ability to recognize small organic molecules and chemical modifications of host molecules is an essential capability of the adaptive immune system, which until now was thought to be mediated mainly by B cell antigen receptors. Here we report that small molecules, such as cyanine 3 (Cy3), a synthetic fluorescent molecule, and 4-hydroxy-3-nitrophenylacetyl (NP), one of the most noted haptens, are γδ T cell antigens, recognized directly by specific γδ TCRs. Immunization with Cy3 conjugates… CONTINUE READING
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γδ T cells: first line of defense and beyond.

Annual review of immunology • 2014
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