Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.

@article{Ng2001GammaaminobutyricAT,
  title={Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action.},
  author={Gordon Yiu Kon Ng and Sandrine S Bertrand and Ron M. Sullivan and N Ethier and Joanne H. Wang and James Yergey and Michel Belley and Laird Trimble and Kelly Bateman and Luanda Alder and Adrian Edward Smith and Ruth Mckernan and Kathleen M. Metters and Gary P. O'neill and J. C. Lacaille and Terence E. H{\'e}bert},
  journal={Molecular pharmacology},
  year={2001},
  volume={59 1},
  pages={
          144-52
        }
}
Gamma-aminobutyric acid (GABA) activates two qualitatively different inhibitory mechanisms through ionotropic GABA(A) multisubunit chloride channel receptors and metabotropic GABA(B) G protein-coupled receptors. Evidence suggests that pharmacologically distinct GABA(B) receptor subtypes mediate presynaptic inhibition of neurotransmitter release by reducing Ca2+ conductance, and postsynaptic inhibition of neuronal excitability by activating inwardly rectifying K+ (Kir) conductance. However, the… CONTINUE READING

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