Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome

  title={Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome},
  author={F. Jim{\'e}nez-Jim{\'e}nez and Gara Esguevillas and H. Alonso-Navarro and M. Zurdo and L. Turpı́n-Fenoll and J. Mill{\'a}n-Pascual and Teresa Adeva-Bartolom{\'e} and E. Cubo and F. Navacerrada and Gemma Amo and A. Rojo-Sebasti{\'a}n and L. Rubio and M. Diez-Fairen and P. P{\'a}stor and M. Calleja and J. F. Plaza-Nieto and B. Pilo-de-la-Fuente and M. Arroyo-Solera and E. Garc{\'i}a-Albea and J. Ag{\'u}ndez and E. Garc{\'i}a-Mart{\'i}n},
  journal={The Pharmacogenomics Journal},
The possible role of gammaaminobutyric acid (GABA) in the pathophysiology of restless legs syndrome (RLS) is suggested by the symptomatic improvement achieved with GABAergic drugs. Thalamic GABA levels have shown positive correlation with periodic limb movements indices and with RLS severity. We tried to investigate the possible association between the most common single nucleotide polymorphisms (SNPs) in the GABA receptors (GABR) genes rho1, 2, and 3 (GABRR1, GABRR2, GABRR3), alpha4 (GABRA4… Expand
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