Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome

  title={Gamma-aminobutyric acid (GABA) receptors genes polymorphisms and risk for restless legs syndrome},
  author={F{\'e}lix Javier Jim{\'e}nez‐Jim{\'e}nez and Gara Esguevillas and Hortensia Alonso-Navarro and Martı́n Zurdo and Laura Turpı́n-Fenoll and Jorge Mill{\'a}n-Pascual and Teresa Adeva-Bartolom{\'e} and Esther Cubo and Francisco Navacerrada and Gemma Amo and Ana Rojo-Sebasti{\'a}n and Lluisa Rubio and M{\'o}nica Diez-Fairen and Pau P{\'a}stor and Marisol Calleja and Jos{\'e} Francisco Plaza-Nieto and Bel{\'e}n Pilo-de-la-Fuente and Margarita Arroyo-Solera and Esteban Garc{\'i}a-Albea and Jos{\'e} A. G. Ag{\'u}ndez and Elena Garc{\'i}a-Mart{\'i}n},
  journal={The Pharmacogenomics Journal},
The possible role of gammaaminobutyric acid (GABA) in the pathophysiology of restless legs syndrome (RLS) is suggested by the symptomatic improvement achieved with GABAergic drugs. Thalamic GABA levels have shown positive correlation with periodic limb movements indices and with RLS severity. We tried to investigate the possible association between the most common single nucleotide polymorphisms (SNPs) in the GABA receptors (GABR) genes rho1, 2, and 3 (GABRR1, GABRR2, GABRR3), alpha4 (GABRA4… 

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