Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor

@article{GarcaMartn2010GammaaminobutyricA,
  title={Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor},
  author={Elena Garc{\'i}a-Mart{\'i}n and Carmen Martı́nez and Hortensia Alonso-Navarro and Juli{\'a}n Benito-Le{\'o}n and Oswaldo Lorenzo-Betancor and Pau P{\'a}stor and Inmaculada Puertas and Lluisa Rubio and Tom{\'a}s L{\'o}pez-Alburquerque and Jos{\'e} A. G. Ag{\'u}ndez and F{\'e}lix Javier Jim{\'e}nez‐Jim{\'e}nez},
  journal={Journal of Neurology},
  year={2010},
  volume={258},
  pages={203-211}
}
Some clinical and experimental data suggest a possible role of gamma-aminobutyrate (GABA)-ergic mechanisms in the pathophysiology of essential tremor (ET), such as the improvement of ET with some GABAergic drugs and the development of an experimental model of ET in GABA A receptor alpha-1 knockout mice (postural and kinetic tremor and motor incoordination similar to human ET). To investigate the possible association between the GABA receptor subtype rho1, rho2, and rho3 (GABRR1, GABRR2, and… 

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It is reported that γ-aminobutyric acidA (GABAA) receptor α1–/– mice exhibit postural and kinetic tremor and motor incoordination that is characteristic of essential tremor disease.

Dopamine receptor D3 (DRD3) genotype and allelic variants and risk for essential tremor

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LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease

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Dopamine receptor D3 gene and essential tremor in large series of German, Danish and French patients

It is suggested that the Ser9Gly variant, located in the ETM1 locus on chromosome 3q13.3, is unlikely to be a causal factor for essential tremor, and the DRD3 variant was not found linked to the disease in a subset of informative ET families.

LINGO1 polymorphisms are associated with essential tremor in Europeans

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The effect of theophylline on essential tremor: The possible role of GABA