Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma

  title={Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma},
  author={Hildegard M. Schuller and Hussein A. N. Al-Wadei and Mourad Majidi},
  pages={1979 - 1985}
Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer in smokers and non-smokers that arises in most cases from small airway epithelial cells. PAC has a high mortality due to its aggressive behavior and resistance to cancer therapeutics. We have shown previously that the proliferation of human PAC cells NCI-H322 and immortalized human small airway epithelial cells HPL1D is stimulated by cyclic adenosine monophosphate (cAMP)/protein kinase A-dependent phosphorylation of cyclic… CONTINUE READING
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