Gamma-Hydroxybutyrate, a Normal Brain Metabolite

  title={Gamma-Hydroxybutyrate, a Normal Brain Metabolite},
  author={Samuel P. Bessman and William N Fishbein},
THE finding that γ-aminobutyric acid undergoes an omega transamination to succinic semialdehyde in brain1 and the subsequent description of a specific dehydrogenase for succinic semialdehyde2,3 indicated a complete pathway parallel to the Krebs cycle in the brain, which by-passed α-ketoglutarate dehydrogenase—a slow step in the cycle4. It was reported in the initial investigation, which demonstrated succinic semialdehyde as an intermediate, that this compound could also effect the oxidation of… CONTINUE READING