• Corpus ID: 32170959

Gamma-Aminobutyric Acid ( GABA ) Introduction

  title={Gamma-Aminobutyric Acid ( GABA ) Introduction},
  • Biology

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Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans.
GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety and GABA administration could enhance immunity under stress conditions.
Extrasynaptic GABAA receptors are critical targets for sedative-hypnotic drugs.
  • B. Orser
  • Biology
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
  • 2006
The functional, regional distribution, and pharmacologic properties of various classes of GABAA receptors are summarized and the probable contribution of extrasynaptic GAB AA receptors in the modulation of sleep will be considered.
Tics in Tourette Syndrome: New Treatment Options
  • Y. Awaad
  • Medicine, Psychology
    Journal of child neurology
  • 1999
Baclofen/botolinum toxin type A are very effective, safe, and reliable in the treatment of tics/Tourette's syndrome and it is worthwhile considering this treatment approach in patients with tics in order to reduce or avoid the side effects of other medications.
Brain Gamma-Aminobutyric Acid Levels Are Decreased in Patients With Phantageusia and Phantosmia Demonstrated by Magnetic Resonance Spectroscopy
It is indicated that decreased brain GABA levels can serve as biochemical markers of phantageusia and/or phantosmia in patients with these distortions and are the first biochemical changes in the CNS that reflect these sensory changes.
[Gabapentin (GBP) in panic disorders--case report].
Adverse events were not observed and an addition of gabapentin into treatment brings improvement of the clinical condition and the presented case reports show a possibility of successful treatment with gabAPentin in severe panic disorders.
GABAergic Mechanisms in Epilepsy
Summary: γ‐Aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tone that counterbalances neuronal excitation. When this balance is
Beyond Monoamines: Glutamatergic Function in Mood Disorders
A hypothetical model of altered glutamatergic function in mood disorders is proposed in conjunction with potential antidepressant mechanisms of antiglutamater gic agents, likely to provide new targets for the development of novel antidepressant agents.
Effects of Gabapentin on the Motor Response to Levodopa: A Double-Blind, Placebo-Controlled, Crossover Study in Patients With Complicated Parkinson Disease
Gabapentin improved parkinsonian symptoms and magnitude of the motor response following levodopa, and this improvement was not reflected in the daily motor situation of patients.
Liposome‐entrapped GABA modifies behavioral and electrographic changes of penicillin‐induced epileptic activity
LEG decreased or prevented the epileptic activity, whereas no significant changes were seen with either GABA or phosphatidylserine given alone, suggesting LEG may enhance penetration of GABA across the blood-brain barrier because of the carrier action of the liposomes.
Efflux of a suppressive neurotransmitter, GABA, across the blood–brain barrier
It is likely that GABA inhibits the first step in the abluminal membrane uptake by brain endothelial cells, and that probenecid selectively inhibits the luminal membrane efflux transport process from the brain capillary endothelial Cells based on the in vivo and in vitro evidence.