Gamma‐Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine

@article{GarcaMartn2017GammaAminobutyricA,
  title={Gamma‐Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine},
  author={Elena Garc{\'i}a-Mart{\'i}n and Carmen Martı́nez and Mercedes Serrador and Hortensia Alonso-Navarro and Francisco Navacerrada and Gara Esguevillas and Esteban Garc{\'i}a-Albea and Jos{\'e} A. G. Ag{\'u}ndez and F{\'e}lix Javier Jim{\'e}nez-Jim{\'e}nez},
  journal={Headache: The Journal of Head and Face Pain},
  year={2017},
  volume={57}
}
The possible role of gammaaminobutyric acid (GABA) in the pathogenesis of migraine has been suggested by a number of biochemical, pharmacological, neurophysiological and experimental data. We investigated the possible association between the most common single nucleotide polymorphisms (SNPs) in the GABA receptor rho1, 2, and 3 genes (GABRR1, GABRR2, and GABRR3) and the risk of developing migraine. 
7 Citations
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References

SHOWING 1-10 OF 77 REFERENCES
Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
TLDR
This study has performed an association analysis in a large population of case-controls examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region of the GABRE gene and also the I478F coding variant of theGABRQ gene, which did not show any association between the examined SNPs in the test population. Expand
Histamine‐N‐Methyl Transferase Polymorphism and Risk for Migraine
TLDR
Investigation of the possible association between HNMT polymorphism and the risk for migraine found one of these single nucleotide polymorphisms causes the amino acid substitution Thr105Ile, related to decreased enzyme activity. Expand
Dopamine receptor 3(DRD3) polymorphism and risk for migraine
TLDR
This work investigated the possible association between the polymorphism 312G>A (rs6280) in the DRD3 gene and the risk for migraine and for triggering migraine attacks by alcohol. Expand
Interaction between γ-Aminobutyric Acid A Receptor Genes: New Evidence in Migraine Susceptibility
TLDR
For the first time, the putative involvement of polymorphisms in GABAAR genes in migraine susceptibility is shown and a role for novel gene-gene interactions is unraveled opening new perspectives for the development of more effective treatments. Expand
Neuronal Nitric Oxide Synthase (nNOS, NOS1) rs693534 and rs7977109 Variants and Risk for Migraine
TLDR
This work investigated the possible association between functional single nucleotide polymorphisms in the neuronal nitric oxide synthase gene (NOS1 or nNOS; chromosome 12q24.22) and the risk for migraine. Expand
No association of migraine to the GABA‐A receptor complex on chromosome 15
  • G. Oswell, M. Kaunisto, +6 authors A. Palotie
  • Biology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
TLDR
An extensive association study using 898 MA cases and 900 matched controls by covering the same gene cluster with 34 single nucleotide polymorphisms (SNPs) suggested that common variants of the GABA cluster are unlikely to be major contributors of MA susceptibility. Expand
Significant differences in gene expression of GABA receptors in peripheral blood leukocytes of migraineurs.
TLDR
There may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 and GABBR2 genes, which are identified as potential biomarkers to select migraineurs that may be more responsive to GABA agonists. Expand
The Actions of Valproate and Neurosteroids in a Model of Trigeminal Pain
TLDR
The effect of valproate and allopregnanolone, a metabolite of progesterone, which binds and modulates the GABA receptor in an animal model of cephalic pain is tested. Expand
Diamine Oxidase rs10156191 and rs2052129 Variants Are Associated With the Risk for Migraine
TLDR
This work investigated the possible association between functional single nucleotide polymorphisms in the diamine oxidase gene (DAO; chromosome 7q36.1, involved in histamine metabolism) and the risk for migraine. Expand
Investigation of the role of the GABRG2 gene variant in migraine
TLDR
The results did not support a role for the tested GABRG2 variant in migraine and no differences were detected for subtypes or for a specific gender of migraine. Expand
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