Gamma‐Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine

@article{GarcaMartn2017GammaAminobutyricA,
  title={Gamma‐Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine},
  author={Elena Garc{\'i}a-Mart{\'i}n and Carmen Martı́nez and Mercedes Serrador and Hortensia Alonso-Navarro and Francisco Navacerrada and Gara Esguevillas and Esteban Garc{\'i}a-Albea and Jos{\'e} A. G. Ag{\'u}ndez and F{\'e}lix Javier Jim{\'e}nez‐Jim{\'e}nez},
  journal={Headache: The Journal of Head and Face Pain},
  year={2017},
  volume={57}
}
The possible role of gammaaminobutyric acid (GABA) in the pathogenesis of migraine has been suggested by a number of biochemical, pharmacological, neurophysiological and experimental data. We investigated the possible association between the most common single nucleotide polymorphisms (SNPs) in the GABA receptor rho1, 2, and 3 genes (GABRR1, GABRR2, and GABRR3) and the risk of developing migraine. 
12 Citations

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The frequencies of NOS3 rs2070744 genotypes and allelic variants were not associated with the risk for migraine and were not influenced by age at onset of migraine, gender, presence of aura, or triggering of migraine attacks by ethanol.

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GABA AND GLUTAMATE CHANGES IN PEDIATRIC MIGRAINE

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It was found that children with migraine and aura had significantly lower glutamate levels in the visual cortex as compared to control children, opposite to results seen in adults and highlights the need for further mechanistic studies of migraine in children, to aid in the development of more effective treatments.

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Using magnetic resonance spectroscopy in vivo, GABA and glutamate alterations in children aged 7 to 13 years with migraine are shown, which are associated with migraine characteristics.

Role of Omics in Migraine Research and Management: A Narrative Review.

TLDR
A review of the genomic alterations especially involved in the regulation of glutamatergic neurotransmission, cortical excitability, ion channels, solute carrier proteins, or receptors in migraine patients and also specific proteins and metabolites, including some inflammatory biomarkers that might represent the migraine phenotype at the molecular level are focused on.

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