Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.

@article{Decaluwe2010GammacDP,
  title={Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.},
  author={H{\'e}l{\`e}ne Decaluwe and Morgan Taillardet and Erwan Corcuff and Ivana Munitic and Helen K. W. Law and Benedita Rocha and Yves Rivi{\`e}re and James P Di Santo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 20},
  pages={9311-6}
}
Several cytokines (including IL-2, IL-7, IL-15, and IL-21) that signal through receptors sharing the common gamma chain (gamma(c)) are critical for the generation and peripheral homeostasis of naive and memory T cells. Recently, we demonstrated that effector functions fail to develop in CD4(+) T cells that differentiate in the absence of gamma(c). To assess the role of gamma(c) cytokines in cell-fate decisions that condition effector versus memory CD8(+) T cell generation, we compared the… CONTINUE READING

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