Gamete vaccines and transmission-blocking immunity in malaria.

  title={Gamete vaccines and transmission-blocking immunity in malaria.},
  author={Robert W. Gwadz and Richard P Carter and Ira Green},
  journal={Bulletin of the World Health Organization},
  volume={57 Suppl 1},
We have recently proposed an approach to malaria control based on immunization of the host against extracellular malarial gametes, the stage in the mosquito guts, in order to block transmission by the mosquito vector. Our studies with avian and primate models have demonstrated that immunization of the host with extracellular gametes totally suppresses infectivity to the mosquito of a subsequent blood meal. Gametocytes within the erythrocytes are unaffected by the immunity, since resuspending… CONTINUE READING

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