Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl‐2 and enhancing caspase‐3 activity in human malignant melanoma A375 cells

@article{Xu2009GambogicAI,
  title={Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl‐2 and enhancing caspase‐3 activity in human malignant melanoma A375 cells},
  author={X. Xu and Ye-qiang Liu and L. Wang and J. He and H. Zhang and Xinxiang Chen and Y. Li and J. Yang and J. Tao},
  journal={International Journal of Dermatology},
  year={2009},
  volume={48}
}
  • X. Xu, Ye-qiang Liu, +6 authors J. Tao
  • Published 2009
  • Biology, Medicine
  • International Journal of Dermatology
  • Objectives  To investigate the effect of a Chinese traditional medicine, gambogic acid (GA), on human malignant melanoma (MM) A375 cells and to study the mechanism of apoptosis induced by GA. 
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    References

    SHOWING 1-10 OF 28 REFERENCES
    Role of Apaf‐1, a key regulator of apoptosis, in melanoma progression and chemoresistance
    • 62
    Loss of proapoptotic Bcl-2-related multidomain proteins in primary melanomas is associated with poor prognosis.
    • 76
    A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid.
    • 183
    • PDF
    Hypoxia: dual effect on the expression of transferrin receptor in human melanoma A375 cell line
    • 13