Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl‐2 and enhancing caspase‐3 activity in human malignant melanoma A375 cells

@article{Xu2009GambogicAI,
  title={Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl‐2 and enhancing caspase‐3 activity in human malignant melanoma A375 cells},
  author={Xiaoyuan Xu and Ye-qiang Liu and Ling Wang and Jun He and Hong-feng Zhang and Xinxiang Chen and Yan Li and Jing Yang and Juan Tao},
  journal={International Journal of Dermatology},
  year={2009},
  volume={48}
}
Objectives  To investigate the effect of a Chinese traditional medicine, gambogic acid (GA), on human malignant melanoma (MM) A375 cells and to study the mechanism of apoptosis induced by GA. 
Liang/Zhang: Gambogic Acid Inhibits Melanoma via P66-ROS-p53 Pathway
Background/Aims: Malignant melanoma has high metastatic potential, is highly resistant to chemotherapy, and has a poor survival rate. Gambogic acid (GA), a polyprenylated xanthone extracted from a
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TLDR
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Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS.
TLDR
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Gambogic Acid Inhibits Melanoma through Regulation of miR‐199a‐3p/ZEB1 Signalling
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Gambogic acid exhibits anti-metastatic activity on malignant melanoma mainly through inhibition of PI3K/Akt and ERK signaling pathways.
TLDR
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Gambogic acid induces apoptosis and sensitizes TRAIL-mediated apoptosis through downregulation of cFLIPL in renal carcinoma Caki cells.
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It is suggested that GA induces apoptosis via the downregulation of cFLIPL and sensitized TRAIL-mediated apoptosis in Caki cells.
Gambogic Acid as Anticancer Agent: A Review
TLDR
The current review highlights the anticancer and chemo-preventive perspectives of gambogic acid and its mechanistic role against human and animal cancers.
Enhancement of induced apoptosis in human melanoma A375 by a combination of natural compounds
TLDR
Emodin enhanced the anticancer activity of jaceosidin and magnolol; as such, a combination of emodin with Magnolol was more effective than other combinations and could be considered further in future researches of melanoma.
Enhancement of anticancer efficacy of chemotherapeutics by gambogic acid against gastric cancer cells.
TLDR
GA has a promising role in enhancing the efficacy of 5-FU, Oxa, and Doc in the treatment of gastric cancer and the potential mechanism would be their synergistic effects on apoptosis induction and the downregulation of chemotherapeutic agent-associated genes.
Ferulic acid reduces cell viability through its apoptotic efficacy: an in vitro approach.
TLDR
The cytotoxic potential of ferulic acid might be due to its role in apoptosis induction, excessive ROS generation and DNA fragmentation in Hep-2 cells.
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