Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain.

@article{Yang2012GambogicAD,
  title={Gambogic acid deactivates cytosolic and mitochondrial thioredoxins by covalent binding to the functional domain.},
  author={Jing Yang and Chenglin Li and Li Ding and Qinglong Guo and Qidong You and Shaohong Jin},
  journal={Journal of natural products},
  year={2012},
  volume={75 6},
  pages={1108-16}
}
Gambogic acid (1) is a cytotoxic caged xanthone derived from the resin of Garcinia hanburyi. Compound 1 selectively induces apoptosis in cancer cells, at least partially, by targeting the stress response to reactive oxygen species (ROS). However, the molecular mechanism of ROS toxicity stimulated by 1 remains poorly understood. In this study, mass spectrometric and biochemical pharmacological approaches were used that resulted in the identification of both cytosolic thioredoxin (TRX-1) and… CONTINUE READING

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