Galvanotactic control of collective cell migration in epithelial monolayers.

  title={Galvanotactic control of collective cell migration in epithelial monolayers.},
  author={Daniel J. Cohen and William James Nelson and Michel M. Maharbiz},
  journal={Nature materials},
  volume={13 4},
Many normal and pathological biological processes involve the migration of epithelial cell sheets. This arises from complex emergent behaviour resulting from the interplay between cellular signalling networks and the forces that physically couple the cells. Here, we demonstrate that collective migration of an epithelium can be interactively guided by applying electric fields that bias the underlying signalling networks. We show that complex, spatiotemporal cues are locally interpreted by the… CONTINUE READING
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