Galphai is not required for chemotaxis mediated by Gi-coupled receptors.

@article{Neptune1999GalphaiIN,
  title={Galphai is not required for chemotaxis mediated by Gi-coupled receptors.},
  author={Enid R. Neptune and Taroh Iiri and Henry R. Bourne},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 5},
  pages={2824-8}
}
Pertussis toxin inhibits chemotaxis of neutrophils by preventing chemoattractant receptors from activating trimeric G proteins in the Gi subfamily. In HEK293 cells expressing recombinant receptors, directional migration toward appropriate agonist ligands requires release of free G protein betagamma subunits and can be triggered by agonists for receptors coupled to Gi but not by agonists for receptors coupled to two other G proteins, Gs and Gq. Because activation of any G protein presumably… CONTINUE READING

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